Function of retrosplenial cortex and associated circuits in spatial and non-spatial cognition.

Retrosplenial cortex is anatomically positioned as the interface between the extended hippocampal formation and neocortical regions critical for higher-order cognition and sensorimotor processing. Connectivity between RSC and thalamic, hippocampal, and cortical input and output regions is highly organized suggesting a unique computational processing role for the region in broad cognitive functions. Our laboratory explores circuits centered on RSC in both spatial and non-spatial cognition in health, aging, and disease states. Example research directions include: 

1. Mechanisms and role of spatially-anchored gain modulation observed within the region. 
2. Input-output mapping of RSC afferent and efferent functional connectivity.
3. Functional contributions of genetically-defined sub-types of RSC neurons in spatial cognition. 
4. How does RSC support the construction and use of internal models in non-spatial domains?